Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      QGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSV TQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNS
    • Amino acids
      641 to 740
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • bA386N14.2
    • bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)
    • bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX
    • DKFZp686A03225
    • Histone demethylase UTX
    • KABUK2
    • Kdm6a
    • KDM6A_HUMAN
    • Lysine (K) specific demethylase 6A
    • Lysine K specific demethylase 6A
    • Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome
    • Lysine-specific demethylase 6A
    • MGC141941
    • Ubiquitously transcribed tetratricopeptide repeat X chromosome
    • Ubiquitously transcribed tetratricopeptide repeat protein X linked
    • Ubiquitously transcribed TPR gene on the X chromosome
    • Ubiquitously transcribed TPR protein on the X chromosome
    • Ubiquitously transcribed X chromosome tetratricopeptide repeat protein
    • Ubiquitously-transcribed TPR protein on the X chromosome
    • Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
    • UTX
    see all
  • Function
    Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
  • Sequence similarities
    Belongs to the UTX family.
    Contains 1 JmjC domain.
    Contains 8 TPR repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab159790 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159790 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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