Description

  • Product name

    Recombinant Human KLHDC8B protein (denatured)
  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSAGGGR AFAWQVFPPM PTCRVYGTVA HQDGHLLVLG GCGRAGLPLD TAETLDMASH TWLALAPLPT ARAGAAAVVL GKQVLVVGGV DEVQSPVAAV EAFLMDEGRW ERRATLPQAA MGVATVERDG MVYALGGMGP DTAPQAQVRV YEPRRDCWLS LPSMPTPCYG ASTFLHGNKI YVLGGRQGKL PVTAFEAFDL EARTWTRHPS LPSRRAFAGC AMAEGSVFSL GGLQQPGPHN FYSRPHFVNT VEMFDLEHGS WTKLPRSLRM RDKRADFVVG SLGGHIVAIG GLGNQPCPLG SVESFSLARR RWEALPAMPT ARCSCSSLQA GPRLFVIGGV AQGPSQAVEA LCLRDGV
    • Predicted molecular weight

      40 kDa including tags
    • Amino acids

      1 to 354
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_775817.1.
  • Description

    Recombinant Human KLHDC8B protein

Specifications

Our Abpromise guarantee covers the use of ab187414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 90% PBS, 10% Glycerol

General Info

  • Alternative names

    • FLJ11302
    • FP17659
    • Kelch domain containing 8B
    • Kelch domain containing protein 8B
    • Kelch domain-containing protein 8B
    • KLD8B_HUMAN
    • Klhdc8b
    • MGC35097
    • MGC94736
    see all
  • Involvement in disease

    Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL) [MIM:236000]. A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. Note=A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).
  • Sequence similarities

    Contains 8 Kelch repeats.
  • Developmental stage

    Transcribed predominantly during S phase, translated exclusively during mitosis and cytokinesis and rapidly degraded after cell division.
  • Cellular localization

    Cytoplasm. In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab187414 (3µg).

References

ab187414 has not yet been referenced specifically in any publications.

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