Description

  • Product name

    Recombinant human KMT1B / SUV39H2 protein
  • Biological activity

    Specific Activity: 38 pmol/min/mg.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      26 to 350

Specifications

Our Abpromise guarantee covers the use of ab80288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.0462% DTT, 0.395% Tris HCl, 0.05% Tween, 30% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • FLJ23414
    • H3 K9 HMTase 2
    • H3-K9-HMTase 2
    • Histone H3 K9 methyltransferase 2
    • Histone H3-K9 methyltransferase 2
    • Histone lysine N methyltransferase H3 lysine 9 specific 2
    • Histone lysine N methyltransferase SUV39H2
    • Histone-lysine N-methyltransferase SUV39H2
    • KMT1B
    • Lysine N methyltransferase 1B
    • Lysine N-methyltransferase 1B
    • sSuppressor of variegation 3 9 homolog 2 (Drosophila)
    • Su(var)3 9 Drosophila homolog of 2
    • Su(var)3 9 homolog 2
    • Su(var)3-9 homolog 2
    • Suppressor of variegation 3 9 homolog 2
    • Suppressor of variegation 3-9 homolog 2
    • Suv39h2
    • SUV92_HUMAN
    see all
  • Function

    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
  • Sequence similarities

    Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.
    Contains 1 chromo domain.
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • Domain

    Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.
  • Cellular localization

    Nucleus. Chromosome > centromere. Associates with centromeric constitutive heterochromatin.
  • Information by UniProt

Images

  • Image showing specific activity of ab80288.
  • 10% SDS-PAGE showing ab80288 at approximately 63kDa (3µg).

References

ab80288 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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