Overview

  • Product name

    Recombinant Human Lambda Light chain protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MAWTPLLLPLLTFCTVSEASYDLTQPPSVSVSPGQTARITCSGDALPRKY AFWYQQKSGQAPVLVIYEDSKRPSGIPERFSGSSSGTMATLTISGAQVED EGDYYCYSTDISGYPVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKA TLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSL TPEQWRSHKSYSCQVTHEGSTVEKTVAPTECS
    • Amino acids

      1 to 232
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158750 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Bence Jones protein
    • BJP
    • Constant region of lambda light chains
    • Ig lambda chain C regions
    • ig lambda-6 chain C region
    • IGLC
    • IGLC 1
    • IGLC 2
    • IGLC 3
    • IGLC1
    • IGLC2
    • IGLC3
    • IGLC6
    • IGLV
    • Immunoglobulin lambda constant 1
    • Immunoglobulin lambda constant regin 1
    • immunoglobulin lambda gene cluster
    • Immunoglobulin lambda locus
    • Immunoglobulin lambda variable cluster
    • Immunoglobulin: lambda light chain
    • Mcg marker
    • Paraprotein
    see all
  • Relevance

    All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
  • Cellular localization

    Cytoplasmic

Images

  • ab158750 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158750 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab158750.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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