Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MASMTGGQQMGRGHHHHHHENLYFQGGEFIQVFLLGGSRKRVLVRVERAT VYSVEQDNDLELADAYYLGGVPPDQLPPSLRRLFPTGGSVRGCVKGIKAL GKYVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFLRLALSNVAPLTGNV YSGFGFHSAQDSALLYYRASPDGLCQVSLQQGRVSLQLLRTEVKTQAGFA DGAPHYVAFYSNATGVWLYVDDQLQQMKPHRGPPPELQPQPEGPPRLLLG GLPESGTIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTGCAPALQ AQTPGLGPRGLQATARKASRRSRQPARHPACMLPPHLRTTRDSYQFGGSL SSHLEFVGILARHRNWPSLSMHVLPRSSRGLLLFTARLRPGSPSLALFLS NGHFVAQMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAW SQEGPHRQHQGAEHPQPHTLFVGGLPASSHSSKLP
    • Molecular weight

      53 kDa including tags
    • Amino acids

      3027 to 3482
    • Additional sequence information

      Corresponds to the C-terminal of extracellular domain. T7-His-TEV cleavage site Tag at N terminal end.

Specifications

Our Abpromise guarantee covers the use of ab190413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity

    > 90 % SDS-PAGE.
    This protein is expressed in E.coli as inclusion bodies. The final product was refolded using temperature shift inclusion body refolding technology and chromatographically purified.
  • Form

    Liquid
  • Additional notes

     This product was previously labelled as Laminin alpha 5

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituent: 0.32% Tris HCl

    Contains NaCl, KCl, EDTA, arginine, DTT and Glycerol.

General Info

  • Alternative names

    • KIAA0533
    • KIAA1907
    • LAMA5
    • LAMA5_HUMAN
    • Laminin alpha 5 chain
    • Laminin subunit alpha 5
    • Laminin subunit alpha-5
    • Laminin, alpha 5
    • Laminin-10 subunit alpha
    • Laminin-11 subunit alpha
    • Laminin-15 subunit alpha
    • RP11-157P1.6
    see all
  • Function

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificity

    Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
  • Sequence similarities

    Contains 22 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
    Contains 1 laminin IV type A domain.
    Contains 1 laminin N-terminal domain.
  • Domain

    Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
  • Cellular localization

    Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
  • Information by UniProt

References

ab190413 has not yet been referenced specifically in any publications.

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