Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEP
    • Molecular weight

      32 kDa including tags
    • Amino acids

      65 to 328
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_056532.

Specifications

Our Abpromise guarantee covers the use of ab202625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.
    ab202625 was purified by conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 10% Glycerol, 0.24% Tris buffer

General Info

  • Alternative names

    • C type lectin domain family 4 member K
    • C-type lectin domain family 4 member K
    • CD 207
    • CD207
    • CD207 antigen
    • CD207 antigen, langerin
    • CD207 molecule
    • CLC4K_HUMAN
    • CLEC 4K
    • CLEC4K
    • Langerhans cell specific c type lectin
    • Langerin
    • RGD1565913
    see all
  • Function

    Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • Tissue specificity

    Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • Involvement in disease

    Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
  • Cellular localization

    Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab202625 (3μg).

References

ab202625 has not yet been referenced specifically in any publications.

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