The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Endometrial bleeding associated factor
Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily)
Endometrial bleeding-associated factor
Left right determination factor 2
Left right determination factor A
Left-right determination factor 2
Left-right determination factor A
LFTY2 transforming growth factor, beta -4
LFTY2, mouse, homolog of
Protein lefty 2
Protein lefty A
TGF beta 4
Transforming growth factor beta 4
Transforming growth factor beta-4
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Mesenchymal cells of the endometrial stroma.
Involvement in disease
Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
Belongs to the TGF-beta family.
Transiently expressed before and during menstrual bleeding.
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.