Recombinant Human LEFTY2 protein (His tag) (ab215580)

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Description

  • Product name

    Recombinant Human LEFTY2 protein (His tag)

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Mammalian

  • Accession

    O00292

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      HHHHHHFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLF QEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVH ESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRF ASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYID LQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASET ASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP

    • Predicted molecular weight

      33 kDa including tags

    • Amino acids

      78 to 366

    • Tags

      His tag N-Terminus

    • Additional sequence information

      Full length mature chain without signal peptide, without propeptide.

Specifications

Our Abpromise guarantee covers the use of ab215580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C.

    pH: 7.40
    Constituent: PBS

  • Reconstitution
    Reconstitute with ddH2O to a concentration no less than 100 µg/mL.Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

General Info

  • Alternative names

    • EBAF
    • Endometrial bleeding associated factor
    • Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily)
    • Endometrial bleeding-associated factor
    • Left right determination factor 2
    • Left right determination factor A
    • Left-right determination factor 2
    • Left-right determination factor A
    • LEFTA
    • LEFTY 2
    • LEFTY2
    • LEFTYA
    • LFTY2 transforming growth factor, beta -4
    • LFTY2, mouse, homolog of
    • LFTY2_HUMAN
    • MGC46222
    • Protein lefty 2
    • Protein lefty A
    • Protein lefty-2
    • Protein lefty-A
    • Protein lefty2
    • PSEC0024
    • TGF beta 4
    • TGF-beta-4
    • TGFB4
    • Transforming growth factor beta 4
    • Transforming growth factor beta-4
    see all

  • Function

    Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

  • Tissue specificity

    Mesenchymal cells of the endometrial stroma.

  • Involvement in disease

    Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.

  • Sequence similarities

    Belongs to the TGF-beta family.

  • Developmental stage

    Transiently expressed before and during menstrual bleeding.

  • Post-translational
    modifications

    The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab215580 has not yet been referenced specifically in any publications.

Publishing research using ab215580? Please let us know so that we can cite the reference in this datasheet.

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