Recombinant human Leptin protein (ab168049)
- Datasheet
- References
- Protocols
Overview
-
Product nameRecombinant human Leptin protein
See all Leptin proteins and peptides -
Protein lengthFull length protein
Description
-
NatureRecombinant
-
SourceEscherichia coli
-
Amino Acid Sequence
-
Accession
-
SpeciesHuman
-
SequenceVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILT LSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPW ASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
-
Molecular weight16 kDa
-
Amino acids22 to 167
-
Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab168049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Biological activityab168049 induces proliferation of BAF/3 cells stably transfected with the long form of Human leptin receptor.
-
Applications
Functional Studies
SDS-PAGE
-
Endotoxin level< 0.100 Eu/µg
-
Purity>= 98 % SDS-PAGE.
-
FormLyophilised
-
Additional notesab168049 induces proliferation of BAF/3 cells stably transfected with the long form of Human leptin receptor.
-
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Constituent: 0.038% Sodium bicarbonate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
-
ReconstitutionReconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing 0.1% HSA or BSA. After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
General Info
-
Alternative names
- FLJ94114
- LEP
- LEP_HUMAN
see all -
FunctionMay function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
-
Involvement in diseaseDefects in LEP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
-
Sequence similaritiesBelongs to the leptin family.
-
Cellular localizationSecreted.
- Information by UniProt
Datasheets and documents
References
ab168049 has not yet been referenced specifically in any publications.
