The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
CD85 antigen-like family member K
Immunoglobulin-like transcript 3
Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4
Leukocyte immunoglobulin-like receptor 5
Leukocyte immunoglobulin-like receptor subfamily B member 4
Monocyte inhibitory receptor HM18
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment.