Overview

  • Product name

    Recombinant Human LIN7C protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGCSHHHHHH SSGLVPRGSH MGSMAALGEP VRLERDICRA IELLEKLQRS GEVPPQKLQA LQRVLQSEFC NAVREVYEHV YETVDISSSP EVRANATAKA TVAAFAASEG HSHPRVVELP KTEEGLGFNI MGGKEQNSPI YISRIIPGGI ADRHGGLKRG DQLLSVNGVS VEGEHHEKAV ELLKAAQGKV KLVVRYTPKV LEEMESRFEK MRSAKRRQQT
    • Molecular weight

      24 kDa including tags
    • Amino acids

      1 to 197
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab137173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab137173 was purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 30% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • LIN 7 C
    • Lin 7 homolog C (C. elegans)
    • LIN 7 protein 3
    • LIN 7C
    • LIN7 protein 3
    • MALS 3
    • MALS3
    • Mammalian lin seven protein 3
    • Protein lin 7 homolog C
    • Veli 3
    • Veli 3 protein
    • VELI3
    • Vertebrate lin 7 homolog 3
    see all
  • Relevance

    LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • Cellular localization

    Cell membrane. Peripheral membrane protein. Basolateral cell membrane. Cell junction. Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells.

Images

  • 15% SDS-PAGE analysis of ab137173 (3µg)

References

ab137173 has not yet been referenced specifically in any publications.

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