Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab59008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    > 95 % SDS-PAGE.
    0.2 µm filtered solution.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 25mM HEPES, 1mM DTT, pH 7.5

General Info

  • Alternative names
    • Baculoviral IAP repeat containing 7
    • Baculoviral IAP repeat containing protein 7
    • Baculoviral IAP repeat-containing protein 7
    • BIRC 7
    • birc7
    • BIRC7_HUMAN
    • KIAP
    • Kidney inhibitor of apoptosis protein
    • Livin
    • Livin inhibitor of apotosis
    • Melanoma inhibitor of apoptosis protein
    • ML IAP
    • ML-IAP
    • MLIAP
    • RING finger protein 50
    • RNF 50
    • RNF50
    see all
  • Function
    Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • Tissue specificity
    Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • Sequence similarities
    Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • Cellular localization
    Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt

References

ab59008 has not yet been referenced specifically in any publications.

Publishing research using ab59008? Please let us know so that we can cite the reference in this datasheet.

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