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    recombinant-human-lnx1-protein-ab164648.pdf

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Cell Biology Proteolysis / Ubiquitin Proteasome / Ubiquitin Ubiquitin E3 Enzymes Other E3 Ligases
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Recombinant Human Lnx1 protein (ab164648)

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SDS-PAGE - Recombinant Human Lnx1 protein (ab164648)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: WB, ELISA

    Description

    • Product name

      Recombinant Human Lnx1 protein
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        DNVGNLHFLYSELCKGAFHYGLTKDRKRRSQDGCPDGCASLTATAPSPEV SAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERS
      • Amino acids

        19 to 118
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab164648 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • E3 ubiquitin protein ligase LNX
      • Ligand of Numb protein X 1
      • Ligand of numb protein X 1 E3 ubiquitin protein ligase
      • LNX
      • LNX1
      • MPDZ
      • Multi PDZ domain containing protein E3 ubiquitin protein ligase LNX
      • Numb binding protein 1
      • PDZ domain-containing ring finger protein 2
      • PDZRN2
      see all
    • Relevance

      Lnx1 is a membrane-bound protein that is involved in signal transduction and protein interactions. Lnx1 is an E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lnx1 mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
    • Cellular localization

      Cytoplasmic

    Images

    • SDS-PAGE - Recombinant Human Lnx1 protein (ab164648)
      SDS-PAGE - Recombinant Human Lnx1 protein (ab164648)
      ab164648 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab164648? Please let us know so that we can cite the reference in this datasheet.

    ab164648 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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