Recombinant Human Lnx1 protein (ab164648)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human Lnx1 protein -
Expression system
Wheat germ -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
DNVGNLHFLYSELCKGAFHYGLTKDRKRRSQDGCPDGCASLTATAPSPEV SAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERS -
Amino acids
19 to 118 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab164648 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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Form
Liquid -
Additional notes
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- E3 ubiquitin protein ligase LNX
- Ligand of Numb protein X 1
- Ligand of numb protein X 1 E3 ubiquitin protein ligase
see all -
Relevance
Lnx1 is a membrane-bound protein that is involved in signal transduction and protein interactions. Lnx1 is an E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lnx1 mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. -
Cellular localization
Cytoplasmic
Images
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SDS-PAGE - Recombinant Human Lnx1 protein (ab164648)ab164648 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab164648 has not yet been referenced specifically in any publications.
