Recombinant Human LONP1/Lon protein (ab160451)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: WB, ELISA
Description
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Product name
Recombinant Human LONP1/Lon protein -
Expression system
Wheat germ -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASP PWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGS AGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLV ELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDL GDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDEL SARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTI RDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVL EETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDN HSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKR ILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVG GMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQ GDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLR DRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLI KQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPV FTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSL EVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATP KDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTI AAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDE QAEALAVER -
Amino acids
1 to 959 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab160451 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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Form
Liquid -
Additional notes
This product was previously labelled as LONP1.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- hLON
- hLON ATP dependent protease
- LON
see all -
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. -
Tissue specificity
Duodenum, heart, lung and liver, but not thymus. -
Involvement in disease
CODAS syndrome -
Sequence similarities
Belongs to the peptidase S16 family.
Contains 1 Lon domain. -
Cellular localization
Mitochondrion matrix. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab160451 has not yet been referenced specifically in any publications.