Description

  • Product name

    Recombinant Human LOX 1 protein (His tag)
    See all LOX 1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    ab222959 was purified by using conventional chromatography techniques.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Baculovirus infected insect cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      ADPMQLSQVS DLLTQEQANL THQKKKLEGQ ISARQQAEEA SQESENELKE MIETLARKLN EKSKEQMELH HQNLNLQETL KRVANCSAPC PQDWIWHGEN CYLFSSGSFN WEKSQEKCLS LDAKLLKINS TADLDFIQQA ISYSSFPFWM GLSRRNPSYP WLWEDGSPLM PHLFRVRGAV SQTYPSGTCA YIQRGAVYAE NCILAAFSIC QKKANLRAQH HHHHH
    • Predicted molecular weight

      26 kDa including tags
    • Amino acids

      58 to 273
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Extracellular domain.

Specifications

Our Abpromise guarantee covers the use of ab222959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 10% Glycerol, PBS

General Info

  • Alternative names

    • C-type lectin domain family 8 member A
    • CLEC8A
    • hLOX 1
    • hLOX-1
    • Lectin like oxidized LDL receptor 1
    • Lectin like oxLDL receptor 1
    • Lectin type oxidized LDL receptor 1
    • Lectin-like oxidized LDL receptor 1
    • Lectin-like oxLDL receptor 1
    • Lectin-type oxidized LDL receptor 1
    • low density lipoprotein oxidized, receptor 1
    • LOX-1
    • LOXIN
    • Olr1
    • OLR1_HUMAN
    • Ox LDL receptor 1
    • Ox-LDL receptor 1
    • Oxidised low density lipoprotein (lectin like) receptor 1
    • Oxidized low density lipoprotein receptor 1
    • Oxidized low density lipoprotein receptor 1 soluble form
    • Oxidized low-density lipoprotein receptor 1
    • OxLDL receptor 1
    • SCARE1
    • Scavenger receptor class E, member 1
    • SLOX1
    • soluble form
    • SR-EI
    see all
  • Function

    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • Tissue specificity

    Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
  • Involvement in disease

    Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
    Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    The cytoplasmic region is required for subcellular sorting on the cell surface.
    The C-type lectin domain mediates the recognition and binding of oxLDL.
  • Post-translational
    modifications

    The intrachain disulfide-bonds prevent N-glycosylation at some sites.
    N-glycosylated.
  • Cellular localization

    Cell membrane. Secreted. A secreted form also exists.
  • Information by UniProt

Images

  • 15% SDS-PAGE - Recombinant Human LOX 1 protein (His tag) (3 µg ab222959).

    28-40 kDa under reducing conditions.

References

ab222959 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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