Recombinant Human LOX protein (Tagged) (ab235010)
Key features and details
- Expression system: Baculovirus infected insect cells
- Purity: > 85% SDS-PAGE
- Tags: His tag C-Terminus, MBP tag N-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human LOX protein (Tagged)
See all LOX proteins and peptides -
Purity
> 85 % SDS-PAGE.
Affinity purified. -
Expression system
Baculovirus infected insect cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
DDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVAD PYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQR VKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEG HKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITD VKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY -
Predicted molecular weight
73 kDa including tags -
Amino acids
169 to 417 -
Tags
His tag C-Terminus , MBP tag N-Terminus -
Additional sequence information
Mature chain without signal peptide, without propeptide. N-terminal MBP-tagged and C-terminal 6xHis-tagged.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab235010 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.20
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
General Info
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Alternative names
- lox
- LYOX
- LYOX_HUMAN
see all -
Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. -
Tissue specificity
Heart, placenta, skeletal muscle, kidney, lung and pancreas. -
Involvement in disease
Defects in LOX may be a cause of cutis laxa autosomal recessive type 1 (ARCL1) [MIM:219100]. -
Sequence similarities
Belongs to the lysyl oxidase family. -
Post-translational
modificationsThe lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. -
Cellular localization
Secreted > extracellular space. - Information by UniProt
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab235010 has not yet been referenced specifically in any publications.