Recombinant Human LTBP1 protein (ab114738)

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SDS-PAGE - Recombinant Human LTBP1 protein (ab114738)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, SDS-PAGE, WB

    Description

    • Product name

      Recombinant Human LTBP1 protein
      See all LTBP1 proteins and peptides

    • Expression system

      Wheat germ

    • Accession

      Q14766-2

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKE EPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLS

      • Predicted molecular weight

        36 kDa including tags

      • Amino acids

        403 to 500

      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab114738 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      SDS-PAGE

      Western blot

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • 9430031G15Rik
      • 9830146M04
      • Latent transforming growth factor beta binding protein 1
      • Latent-transforming growth factor beta-binding protein 1
      • Latent-transforming growth factor beta-binding protein, isoform 1L
      • Latent-transforming growth factor beta-binding protein, isoform 1S
      • LBT1S
      • LTBP-1
      • Ltbp1
      • LTBP1_HUMAN
      • MGC163161
      • TGF-beta1-BP-1
      • Tgfb
      • Transforming growth factor beta-1-binding protein 1
      • Transforming growth factor beta-1-masking protein large subunit
      see all

    • Function

      May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).

    • Tissue specificity

      Isoform Long is found in fibroblasts.

    • Sequence similarities

      Belongs to the LTBP family.
      Contains 18 EGF-like domains.
      Contains 4 TB (TGF-beta binding) domains.

    • Domain

      Associates covalently with small latent TGF-beta complex via domain TB 3.

    • Post-translational
      modifications

      Contains hydroxylated asparagine residues.
      Isoform Short N-terminus is blocked.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human LTBP1 protein (ab114738)
      SDS-PAGE - Recombinant Human LTBP1 protein (ab114738)
      12.5% SDS-PAGE showing ab114738 at approximately 36.41kDa.
      Stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab114738? Please let us know so that we can cite the reference in this datasheet.

    ab114738 has not yet been referenced specifically in any publications.

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