Recombinant Human LTBP1 protein (ab114738)

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Description

  • Product name

    Recombinant Human LTBP1 protein
    See all LTBP1 proteins and peptides

  • Expression system

    Wheat germ

  • Accession

    Q14766-2

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKE EPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLS

    • Predicted molecular weight

      36 kDa including tags

    • Amino acids

      403 to 500

Specifications

Our Abpromise guarantee covers the use of ab114738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid

  • Additional notes

    This protein is best used within three months from the date of receipt.

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 9430031G15Rik
    • 9830146M04
    • Latent transforming growth factor beta binding protein 1
    • Latent-transforming growth factor beta-binding protein 1
    • Latent-transforming growth factor beta-binding protein, isoform 1L
    • Latent-transforming growth factor beta-binding protein, isoform 1S
    • LBT1S
    • LTBP-1
    • Ltbp1
    • LTBP1_HUMAN
    • MGC163161
    • TGF-beta1-BP-1
    • Tgfb
    • Transforming growth factor beta-1-binding protein 1
    • Transforming growth factor beta-1-masking protein large subunit
    see all

  • Function

    May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).

  • Tissue specificity

    Isoform Long is found in fibroblasts.

  • Sequence similarities

    Belongs to the LTBP family.
    Contains 18 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.

  • Domain

    Associates covalently with small latent TGF-beta complex via domain TB 3.

  • Post-translational
    modifications

    Contains hydroxylated asparagine residues.
    Isoform Short N-terminus is blocked.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human LTBP1 protein (ab114738)
    SDS-PAGE - Recombinant Human LTBP1 protein (ab114738)
    12.5% SDS-PAGE showing ab114738 at approximately 36.41kDa.
    Stained with Coomassie Blue.

References

ab114738 has not yet been referenced specifically in any publications.

Publishing research using ab114738? Please let us know so that we can cite the reference in this datasheet.

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