Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
      Q14766-2
    • Species
      Human
    • Sequence
      CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKE EPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLS
    • Molecular weight
      36 kDa including tags
    • Amino acids
      403 to 500

Specifications

Our Abpromise guarantee covers the use of ab114738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 9430031G15Rik
    • 9830146M04
    • Latent transforming growth factor beta binding protein 1
    • Latent-transforming growth factor beta-binding protein 1
    • Latent-transforming growth factor beta-binding protein, isoform 1L
    • Latent-transforming growth factor beta-binding protein, isoform 1S
    • LBT1S
    • LTBP-1
    • Ltbp1
    • LTBP1_HUMAN
    • MGC163161
    • TGF-beta1-BP-1
    • Tgfb
    • Transforming growth factor beta-1-binding protein 1
    • Transforming growth factor beta-1-masking protein large subunit
    see all
  • Function
    May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
  • Tissue specificity
    Isoform Long is found in fibroblasts.
  • Sequence similarities
    Belongs to the LTBP family.
    Contains 18 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • Domain
    Associates covalently with small latent TGF-beta complex via domain TB 3.
  • Post-translational
    modifications
    Contains hydroxylated asparagine residues.
    Isoform Short N-terminus is blocked.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE - LTBP1 protein (ab114738)
    SDS-PAGE - LTBP1 protein (ab114738)
    12.5% SDS-PAGE showing ab114738 at approximately 36.41kDa.
    Stained with Coomassie Blue.

References

ab114738 has not yet been referenced specifically in any publications.

Publishing research using ab114738? Please let us know so that we can cite the reference in this datasheet.

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