Description

  • Product name

    Recombinant Human LXR alpha protein
    See all LXR alpha proteins and peptides
  • Biological activity

    1 unit equals 1 nanogram purified protein.
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      215 to 667

Specifications

Our Abpromise guarantee covers the use of ab81934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    EMSA

  • Form

    Liquid
  • Additional notes

    1 unit equals 1 nanogram purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol

General Info

  • Alternative names

    • Liver X receptor alpha
    • LXR a
    • LXRA
    • NR1H3
    • NR1H3_HUMAN
    • Nuclear receptor subfamily 1 group H member 3
    • Oxysterols receptor LXR alpha
    • Oxysterols receptor LXR-alpha
    • RLD 1
    • RLD1
    see all
  • Function

    Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
  • Tissue specificity

    Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab81934 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number 1193867.

To check the status of the order please contact our Customer Service team and reference this number.

Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.

I wish you the best of luck with your research.

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Answer

Thank you for your email.

Apologies for delay. We unfortunately cannot confirm the protein - the error happened due to mislabelling of the product. It seems there might be LXR beta in it however I can not 100% confirm it but surely it is not LXR alpha.

I am happy sending you a new vial of ab81934; we are however waiting for this item to be in stock this week. Would you like to receive a new correct labelled vial?

Thanks for your cooperation. I will look forward to hearing from you soon.

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