Recombinant Human LYK5 protein (ab164904)
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- References
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Overview
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Product nameRecombinant Human LYK5 protein
See all LYK5 proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNL ARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATF IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH HMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS VKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQM LLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG DSPSHPYHRTFSPHFHHFVEQCLQRNPDARYPCWPGPGLRESRGCSGG
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Amino acids1 to 348
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TagsGST tag N-Terminus
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Additional sequence informationThis sequence is the full length protein isoform 2 (Q7RTN6-2).
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Specifications
Our Abpromise guarantee covers the use of ab164904 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Protein kinase LYK5
- Serologically defined breast cancer antigen NY BR 96
- STE20 related adapter protein
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RelevanceMembers of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
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Cellular localizationCytoplasmic and Nuclear
Images
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SDS-PAGE - Recombinant Human LYK5 protein (ab164904)ab164904 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab164904 has not yet been referenced specifically in any publications.
