Recombinant Human MALT1/MLT protein (ab161189)

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Description

  • Product name

    Recombinant Human MALT1/MLT protein

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPE GRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKG CTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRA TGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEF SQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVA VGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD SKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKA PLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLY YAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLL DMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIF MKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALT DPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNV MIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSK DLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPL IAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVY HSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEI PFSFSDRLRISEK

    • Amino acids

      1 to 813

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

    This product was previously labelled as MALT1.

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Caspase like protein
    • DKFZp434L132
    • IMD12
    • MALT 1
    • MALT associated translocation
    • MALT lymphoma associated translocation
    • MALT lymphoma-associated translocation
    • Malt1
    • MALT1 paracaspase
    • MALT1_HUMAN
    • MLT
    • MLT 1
    • MLT1
    • Mucosa associated lymphoid tissue lymphoma translocation gene 1
    • Mucosa associated lymphoid tissue lymphoma translocation protein 1
    • Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    • Paracaspase
    • Paracaspase-1
    • PCASP1
    see all

  • Function

    Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

  • Tissue specificity

    Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

  • Involvement in disease

    Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

  • Sequence similarities

    Belongs to the peptidase C14B family.
    Contains 1 death domain.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

  • Cellular localization

    Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human MALT1/MLT protein (ab161189)
    SDS-PAGE - Recombinant Human MALT1/MLT protein (ab161189)
    ab161189 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161189 has not yet been referenced specifically in any publications.

Publishing research using ab161189? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Does the Abcam-MALT-1 protein has an N-terminal GST-tag?

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Answer

Thank you for contacting us.

It is correct!. The protein is GST tagged at N-terminal end.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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