Recombinant Human MAP1S protein (ab163010)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MAAVAGSGAAAAPSSLLLVVGSEFGSPGLLTYVLEELERGIRSWDVDPGV CNLDEQLKVFVSRHSATFSSIVKGQRSLHHRGDNLETLVLLNPSDKSLYD ELRNLLLDPASHKLLVLAGPCLEETGELLLQTGGFSPHHFLQVLKDREIR DILATTPPPVQPPILTITCPTFGDWAQLAPAVPGLQGALRLQLRLNPPAQ LPNSEGLCEFLEYVAESLEPPSPFELLEPPTSGGFLRLGRPCCYIFPGGL GDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHPGADSLPG LNSLLRRKLAERSEVAAGGGSWDDRLRRLISPNLGVVFFNACEAASRLAR GEDEAELALSLLAQLGITPLPLSRGPVPAKPTVLFEKMGVGRLDMYVLHP PSAGAERTLACVCALLVWHPAGPGEKVVRVLFPGCTPPACLLDGLVRLQH LRFLREPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPG VARKEPARAEAPRKTEKEAKTPRELKKDPKPSVSRTQPREVRRAASSVPN LKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGS PASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEG SERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSV SFEQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEHRKA VPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPV PLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPP KTARQTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLS ARSEPSEKGGRAPLSRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLD LAYLPSGSSAHLVDEEFFQRVRALCYVISGQDQRKEEGMRAVLDALLASK QHWDRDLQVTLIPTFDSVAMHTWYAETHARHQALGITVLGSNSMVSMQDD AFPACKVEF
    • Amino acids
      1 to 1059
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • BPY2-interacting protein 1
    • BPY2IP1
    • C19orf5
    • FLJ10669
    • MAP-1S
    • MAP1S
    • MAP1S light chain
    • MAP1S_HUMAN
    • MAP8
    • MGC133087
    • microtubule-associated protein 1S
    • Microtubule-associated protein 8
    • Variable charge Y chromosome 2-interacting protein 1
    • VCY2-interacting protein 1
    • VCY2IP-1
    • VCY2IP1
    see all
  • Function
    Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.
  • Tissue specificity
    Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.
  • Sequence similarities
    Belongs to the MAP1 family.
  • Domain
    The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
  • Cellular localization
    Nucleus. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.
  • Information by UniProt

Images

  • ab163010 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163010 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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