Description

  • Product name

    Recombinant human MAP4K6 protein
  • Biological activity

    Specific Activity: 19 nmol/min/mg
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      1 to 320

Associated products

Specifications

Our Abpromise guarantee covers the use of ab55712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    ab43614 (Human Myelin Basic Protein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • B55
    • GCK family kinase MiNK
    • hMINK
    • Map4k6
    • MAPK/ERK kinase kinase kinase 6
    • MEK (MAP/ERK) kinase kinase 6
    • MEK kinase kinase 6
    • MEKKK6
    • MGC21111
    • MINK
    • MINK 1
    • MINK1
    • Misshapen like kinase 1
    • Misshapen NIKs Related kinase
    • Misshapen/NIK related kinase
    • Mitogen activated protein kinase kinase kinase kinase 6
    • RP23-122P1.6
    • Ysk2
    • ZC3
    see all
  • Relevance

    MAP4K6 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. These kinases regulate a wide variety of cellular processes by coupling cell surface receptors to MAPK pathways. This kinase appears to act upstream of the JUN N-terminal pathway and may be involved in brain development. It may also play a role in the response to environmental stress, in cytoskeleton reorganization, cell adhesion, and cell motility. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
  • Cellular localization

    Cytoplasm. Cell junction; synapse; postsynaptic cell membrane; postsynaptic density. Cell projection; axon. Cell projection; dendrite. Isoform 4: Golgi apparatus

Images

  • The specific activity of MAP4K6 (ab55712) was determined to be 22 nmol/min/mg as per activity assay protocol and was equivalent to 22 nmol/min/mg as per radiometric assay
  • SDS PAGE analysis of ab55712
  • SDS-PAGE analysis of ab55712 with molecular weight markers. Approximate molecular weight 61kDa.
  • Kinase assay using ab55712. Specific activity: 19 nmol/min/mg.

References

ab55712 has not yet been referenced specifically in any publications.

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