The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cellular modulator of immune recognition
E3 ubiquitin protein ligase MARCH8
E3 ubiquitin-protein ligase MARCH8
Membrane associated RING CH protein VIII
Membrane associated ring finger (C3HC4) 8
Membrane associated RING finger protein 8
Membrane-associated RING finger protein 8
Membrane-associated RING-CH protein VIII
RING finger protein 178
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Broadly expressed. Present in immature dendritic cells (at protein level).
Protein modification; protein ubiquitination.
Contains 1 RING-CH-type zinc finger.
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.