Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMPFAEDK TYKYICRNFS NFCNVDVVEI LPYLPCLTAR DQDRLRATCT LSGNRDTLWH LFNTLQRRPG WVEYFIAALR GCELVDLADE VASVYQSYQP RTSDRPPDPL EPPSLPAERP GPPTPAAAHS IPYNSCREKE PSYPMPVQET QAPESPGENS EQALQTLSPR AIPRNPDGGP LESSSDLAAL SPLTSSGHQE QDTELGSTHT AGATSSLTPS RGPVSPSVSF QPLARSTPRA SRLPGPTGSV VSTGTSFSSS SPGLASAGAA EGKQGAESDQ AEPIICSSGA EAPANSLPSK VPTTLMPVNT VALKVPANPA SVSTVPSKLP TSSKPPGAVP SNALTNPAPS KLPINSTRAG MVPSKVPTSM VLTKVSASTV PTDGSSRNEE TPAAPTPAGA TGGSSAWLDS SSENRGLGSE LSKPGVLASQ VDSPFSGCFE DLAISASTSL GMGPCHGPEE NEYKSEGTFG IHVAENPSIQ LLEGNPGPPA DPDGGPRPQA DRKFQEREVP CHRPSP
    • Molecular weight

      56 kDa including tags
    • Amino acids

      1 to 513
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab139779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.
    ab139779 is purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • CARD adapter inducing interferon beta
    • CARD adaptor inducing IFN beta
    • Cardif
    • DKFZp666M015
    • FLJ27482
    • FLJ41962
    • IFN B promoter stimulator 1
    • Interferon beta promoter stimulator protein 1
    • Ips 1
    • IPS-1
    • Ips1
    • KIAA1271
    • MAVS
    • MAVS_HUMAN
    • Mitochondrial anti viral signaling protein
    • Mitochondrial Antiviral Signaling
    • Mitochondrial antiviral signaling protein
    • Mitochondrial antiviral-signaling protein
    • Putative NF kappa B activating protein 031N
    • Putative NF-kappa-B-activating protein 031N
    • Virus induced signaling adapter
    • virus induced signaling adaptor
    • Virus-induced-signaling adapter
    • VISA
    see all
  • Function

    Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • Tissue specificity

    Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • Sequence similarities

    Contains 1 CARD domain.
  • Domain

    Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • Post-translational
    modifications

    Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab139779 (3µg).

References

ab139779 has not yet been referenced specifically in any publications.

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