Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDG AWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRAD RVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVG GLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEME FEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHN LGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNN SSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIG CLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTIL INNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLL PPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRS RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGD LNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLA TLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIR WMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAG EFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAED ALNTV
    • Molecular weight

      120 kDa including tags
    • Amino acids

      22 to 876

Specifications

Our Abpromise guarantee covers the use of ab131982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
    Best use within three months from the date of receipt of this protein.

     This product was previously labelled as MCK10

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • CAK
    • CD 167
    • CD167
    • CD167 antigen-like family member A
    • CD167a
    • Cell adhesion kinase
    • DDR
    • DDR 1
    • DDR1
    • DDR1_HUMAN
    • Discoidin domain receptor
    • Discoidin domain receptor tyrosine kinase 1
    • Discoidin receptor tyrosine kinase
    • Discoidin receptor tyrosine kinase isoform a
    • EDDR 1
    • EDDR1
    • Epithelial discoidin domain receptor 1
    • Epithelial discoidin domain-containing receptor 1
    • Epithelial specific receptor kinase
    • HGK2
    • Mammarian carcinoma kinase 10
    • Mammary carcinoma kinase 10
    • MCK-10
    • MCK10
    • NEP
    • Neuroepithelial tyrosine kinase
    • Neurotrophic tyrosine kinase receptor type 4
    • NTRK 4
    • NTRK4
    • OTTHUMP00000029343
    • OTTHUMP00000029344
    • OTTHUMP00000029345
    • OTTHUMP00000029346
    • OTTHUMP00000029347
    • OTTHUMP00000164863
    • OTTHUMP00000164867
    • OTTHUMP00000222080
    • Protein-tyrosine kinase 3A
    • Protein-tyrosine kinase RTK-6
    • PTK 3
    • PTK 3A protein tyrosine kinase 3A
    • PTK3
    • PTK3A
    • Receptor tyrosine kinase NEP
    • RTK 6
    • RTK6
    • TRK E
    • TRKE
    • Tyrosine kinase DDR
    • Tyrosine kinase receptor E
    • Tyrosine-protein kinase CAK
    see all
  • Function

    May be involved in cell-cell interactions and recognition.
  • Tissue specificity

    Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 F5/8 type C domain.
    Contains 1 protein kinase domain.
  • Domain

    The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
  • Cellular localization

    Secreted and Membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE, stained with Coomassie Blue showing ab131982.

References

ab131982 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab131982.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up