Product nameRecombinant human MERTK protein
See all MERTK proteins and peptides
Protein lengthProtein fragment
SourceBaculovirus infected Sf9 cells
Amino Acid Sequence
Amino acids578 to 872
Our Abpromise guarantee covers the use of ab72490 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe Specific activity of ab72490 was determined to be 1231 nmol/min/mg.
ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride, 0.00174% PMSF, 0.0038% EGTA
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- c MER
- c mer proto oncogene tyrosine kinase
FunctionIn case of filovirus infection, seems to function as a cell entry factor.
Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
Involvement in diseaseDefects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
- Information by UniProt
ab72490 has not yet been referenced specifically in any publications.