Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: Flow Cyt, SDS-PAGE
Product nameRecombinant human MERTK protein (Active)
See all MERTK proteins and peptides
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
Purity>= 90 % SDS-PAGE.
Expression systemBaculovirus infected Sf9 cells
Protein lengthProtein fragment
SequenceEDVVIDRNLL ILGKILGEGE FGSVMEGNLK QEDGTSLKVA VKTMKLDNSS QREIEEFLSE AACMKDFSHP NVIRLLGVCI EMSSQGIPKP MVILPFMKYG DLHTYLLYSR LETGPKHIPL QTLLKFMVDI ALGMEYLSNR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI AIESLADRVY TSKSDVWAFG VTMWEIATRG MTPYPGVQNH EMYDYLLHGH RLKQPEDCLD ELYEIMYSCW RTDPLDRPTF SVLRLQLEKL LESLPDVRNQ ADVIY
Predicted molecular weight60 kDa including tags
Amino acids578 to 872
TagsGST tag N-Terminus
Additional sequence informationGenbank: NM_006343
Our Abpromise guarantee covers the use of ab271471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol (glycerin, glycerine), 0.05% Glutathione
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- c MER
- c mer proto oncogene tyrosine kinase
FunctionIn case of filovirus infection, seems to function as a cell entry factor.
Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
Involvement in diseaseDefects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab271471 has not yet been referenced specifically in any publications.