Recombinant Human Methionine Aminopeptidase 2/p67 protein (ab168057)

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Description

  • Product name

    Recombinant Human Methionine Aminopeptidase 2/p67 protein
    See all Methionine Aminopeptidase 2/p67 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab168057 was purified by chromatography.

  • Expression system

    Insect cells

  • Accession

    P50579

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSA AGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKK KKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRT TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKL EDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKI DFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGG EATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTK HLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI KGSYTAQFEHTILLRPTCKEVVSRGDDY

    • Predicted molecular weight

      70 kDa including tags

    • Amino acids

      1 to 478

Specifications

Our Abpromise guarantee covers the use of ab168057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid

  • Additional notes

     This product was previously labelled as Methionine Aminopeptidase 2

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.48% HEPES, 10% Glycerol, 0.88% Sodium chloride, 0.001% Cobalt chloride

General Info

  • Alternative names

    • A930035J23Rik
    • AI047573
    • AL024412
    • Amp2
    • AU014659,
    • EIF 2 associated p67 homolog
    • EIF-2-associated p67
    • Initiation factor 2 associated 67 kDa glycoprotein
    • Initiation factor 2-associated 67 kDa glycoprotein
    • MAP 2
    • MAP2
    • MAP2_HUMAN
    • MetAP 2
    • Metap2
    • Methionine aminopeptidase 2
    • Methionyl aminopeptidase 2
    • MGC102452
    • MGC127390
    • MGC53792
    • MNPEP
    • p67
    • p67eIF2
    • Peptidase M
    • Peptidase M2
    see all

  • Function

    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
    Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

  • Sequence similarities

    Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.

  • Post-translational
    modifications

    Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.

  • Cellular localization

    Cytoplasm. About 30% of expressed METAP2 associates with polysomes.
  • Information by UniProt

References

ab168057 has not yet been referenced specifically in any publications.

Publishing research using ab168057? Please let us know so that we can cite the reference in this datasheet.

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