The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Measured by its binding ability in a functional ELISA.
Immobilized Human MHC Class II Ia at 5 μg/ml (100 μl/well) can bind biotinylated Human Cathepsin L1 with a linear range of 3.2 - 500 ng/ml.
< 1.000 Eu/µg
>95% by SDS-PAGE .
Lyophilized from 0.22 μm filtered solution.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C or -80°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
CD74 molecule, major histocompatibility complex, class II invariant
Gamma chain of class II antigens
HLA class II histocompatibility antigen gamma chain
HLA DR antigens associated invariant chain
HLA DR gamma
HLA-DR antigens-associated invariant chain
Ia antigen associated invariant chain
Ia antigen-associated invariant chain
Ia associated invariant chain
Invariant polpypeptide of major histocompatibility class II antigen associated
La associated invariant chain
Major histocompatibility complex class II invariant chain
MHC HLA DR gamma chain
Probable protein disulfide isomerase ER60 precursor
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Contains 1 thyroglobulin type-1 domain.
Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.