Overview

  • Product name

    Recombinant Human MHF1 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      16 kDa
    • Amino acids

      2 to 137
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • APITD1
    • Apoptosis-inducing TAF9-like domain-containing protein 1
    • apoptosis-inducing, TAF9-like domain 1
    • CENP-S
    • CENPS
    • CENPS_HUMAN
    • Centromere protein S
    • FAAP16
    • FANCM-interacting histone fold protein 1
    • Fanconi anemia-associated polypeptide of 16 kDa
    • MGC32686
    • MHF 1
    see all
  • Function

    DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recorery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. As a component of the APITD1/CENPS complex, is also essential for the stable assembly of the outer kinetchore. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
  • Tissue specificity

    Ubiquitously expressed.
  • Sequence similarities

    Belongs to the TAF9 family.
  • Cellular localization

    Nucleus. Chromosome > centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
  • Information by UniProt

References

ab127775 has not yet been referenced specifically in any publications.

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