Recombinant Human MMP11 protein (ab92861)

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Description

  • Product name

    Recombinant Human MMP11 protein

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab92861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

    Mass Spectrometry

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Preservative: 0.68% Imidazole
    Constituents: 0.0078% Beta mercaptoethanol, 0.316% Tris HCl, 2.9% Sodium chloride

General Info

  • Alternative names

    • Matrix Metalloproteinase 11
    • Matrix metalloproteinase-11
    • MMP-11
    • Mmp11
    • MMP11_HUMAN
    • SL 3
    • SL-3
    • SL3
    • ST3
    • STMY3
    • Stromelysin 3
    • Stromelysin III
    • Stromelysin-3
    see all

  • Function

    May play an important role in the progression of epithelial malignancies.

  • Tissue specificity

    Specifically expressed in stromal cells of breast carcinomas.

  • Sequence similarities

    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.

  • Domain

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.

  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human MMP11 protein (ab92861)
    SDS-PAGE - Recombinant Human MMP11 protein (ab92861)
    10% SDS-PAGE stained with Coomassie Blue.

References

This product has been referenced in:

  • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). Read more (PubMed: 24564996) »
See 1 Publication for this product

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