Recombinant Human MMP11 protein (ab92861)

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SDS-PAGE - Recombinant Human MMP11 protein (ab92861)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Suitable for: SDS-PAGE, WB, ELISA, MS

    Description

    • Product name

      Recombinant Human MMP11 protein

    • Purity

      > 90 % SDS-PAGE.

    • Expression system

      Escherichia coli

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

    Specifications

    Our Abpromise guarantee covers the use of ab92861 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Western blot

      ELISA

      Mass Spectrometry

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Preservative: 0.68% Imidazole
      Constituents: 0.0078% Beta mercaptoethanol, 0.316% Tris HCl, 2.9% Sodium chloride

    General Info

    • Alternative names

      • Matrix Metalloproteinase 11
      • Matrix metalloproteinase-11
      • MMP-11
      • Mmp11
      • MMP11_HUMAN
      • SL 3
      • SL-3
      • SL3
      • ST3
      • STMY3
      • Stromelysin 3
      • Stromelysin III
      • Stromelysin-3
      see all

    • Function

      May play an important role in the progression of epithelial malignancies.

    • Tissue specificity

      Specifically expressed in stromal cells of breast carcinomas.

    • Sequence similarities

      Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.

    • Domain

      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    • Post-translational
      modifications

      The precursor is cleaved by a furin endopeptidase.

    • Cellular localization

      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human MMP11 protein (ab92861)
      SDS-PAGE - Recombinant Human MMP11 protein (ab92861)
      10% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (1)

    Publishing research using ab92861? Please let us know so that we can cite the reference in this datasheet.

    ab92861 has been referenced in 1 publication.

    • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). PubMed: 24564996

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