Can degrade fibrillar type I, II, and III collagens.
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Cytoplasmic granule. Secreted > extracellular space > extracellular matrix. Stored in intracellular granules.