Recombinant Human Moesin protein (ab124306)

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Description

  • Product name

    Recombinant Human Moesin protein
    See all Moesin proteins and peptides

  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P26038

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Predicted molecular weight

      68 kDa

    • Amino acids

      1 to 577

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.00
    Constituent: 0.48% HEPES

General Info

  • Alternative names

    • Epididymis luminal protein 70
    • HEL70
    • Membrane organizing extension spike protein
    • Membrane-organizing extension spike protein
    • MOES_HUMAN
    • Moesin
    • Moesin/anaplastic lymphoma kinase fusion protein
    • Msn
    • MSN/ALK fusion
    see all

  • Function

    Probably involved in connections of major cytoskeletal structures to the plasma membrane.

  • Tissue specificity

    In all tissues and cultured cells studied.

  • Sequence similarities

    Contains 1 FERM domain.

  • Post-translational
    modifications

    Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.

  • Cellular localization

    Cell membrane. Cytoplasm > cytoskeleton. Apical cell membrane. Cell projection > microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Moesin protein (ab124306)
    SDS-PAGE - Recombinant Human Moesin protein (ab124306)
    SDS-PAGE using 1µg of ab124306.

References

This product has been referenced in:

  • Chakraborty PK  et al. G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer. Cancer Res 74:3489-500 (2014). Read more (PubMed: 24755472) »
See 1 Publication for this product

Publishing research using ab124306? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

ab124306: more information on the reconsititution. Is the hepes to be added or is it already there. What does 0.48% HEPES means in the constituents section

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Answer

This is packed as 0.2 mg. This protein is lyophilized from 20mM HEPES, pH7.0.

Resuspend with 200ul distilled water to produce 1 mg/ml concentration.

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