Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      P26038
    • Species
      Human
    • Molecular weight
      68 kDa
    • Amino acids
      1 to 577
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.00
    Constituent: 0.48% HEPES

General Info

  • Alternative names
    • Epididymis luminal protein 70
    • HEL70
    • Membrane organizing extension spike protein
    • Membrane-organizing extension spike protein
    • MOES_HUMAN
    • Moesin
    • Moesin/anaplastic lymphoma kinase fusion protein
    • Msn
    • MSN/ALK fusion
    see all
  • Function
    Probably involved in connections of major cytoskeletal structures to the plasma membrane.
  • Tissue specificity
    In all tissues and cultured cells studied.
  • Sequence similarities
    Contains 1 FERM domain.
  • Post-translational
    modifications
    Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.
  • Cellular localization
    Cell membrane. Cytoplasm > cytoskeleton. Apical cell membrane. Cell projection > microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
  • Information by UniProt

Images

  • SDS-PAGE - Moesin protein (ab124306)
    SDS-PAGE - Moesin protein (ab124306)
    SDS-PAGE using 1µg of ab124306.

References

This product has been referenced in:
  • Chakraborty PK  et al. G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer. Cancer Res 74:3489-500 (2014). Read more (PubMed: 24755472) »

See 1 Publication for this product

Publishing research using ab124306? Please let us know so that we can cite the reference in this datasheet.

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1 Review or Q&A

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ab124306: more information on the reconsititution. Is the hepes to be added or is it already there. What does 0.48% HEPES means in the constituents section

This is packed as 0.2 mg. This protein is lyophilized from 20mM HEPES, pH7.0.

Resuspend with 200ul distilled water to produce 1 mg/ml concentration.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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