• Product name

    Recombinant Human MSX1 protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

  • Nature

    • Species

    • Sequence

    • Predicted molecular weight

      57 kDa including tags
    • Amino acids

      1 to 297

Associated products


Our Abpromise guarantee covers the use of ab152543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications



    Western blot

  • Form

  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • AA675338
    • AI324650
    • Homeobox 7
    • Homeobox protein Hox-7
    • Homeobox protein MSX 1
    • Homeobox protein MSX-1
    • Homeobox protein MSX1
    • Homeobox, msh like 1
    • Homeobox, msh-like 1
    • HOX 7
    • Hox 7.1
    • Hox-7
    • HOX7
    • Hox7.1
    • HYD 1
    • HYD1
    • Msh
    • msh (Drosophila) homeo box homolog 1 (formerly homeo box 7)
    • msh homeo box 1
    • msh homeo box homolog 1
    • Msh homeobox 1
    • Msh homeobox 1 like protein
    • Msh homeobox 1-like protein
    • msh homeobox homolog 1
    • msh homeobox homolog 1 (Drosophila)
    • MSH, Drosophila, Homolog of, 1
    • MSX 1
    • MSX1
    • MSX1_HUMAN
    • Muscle segment homeobox
    • Muscle segment homeobox, Drosophila, Homolog of, 1
    • OFC5
    • OTTHUMP00000115387
    • STHAG1
    see all
  • Function

    Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
  • Tissue specificity

    Expressed in the developing nail bed mesenchyme.
  • Involvement in disease

    Defects in MSX1 are the cause of tooth agenesis selective type 1 (STHAG1) [MIM:106600]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Tooth agenesis selective type 1 can be associated with orofacial cleft in some patients.
    Note=MSX1 is deleted in some patients with Wolf-Hirschhorn syndrome (WHS). WHS results from sub-telomeric deletions in the short arm of chromosome 4.
    Defects in MSX1 are the cause of Witkop syndrome (WITS) [MIM:189500]. WITS is a form of ectodermal dyslasia also called tooth-and-nail syndrome or dysplasia of nails with hypodontia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Witkop syndrome is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.
    Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
  • Sequence similarities

    Belongs to the Msh homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Post-translational

    Sumoylated by PIAS1, desumoylated by SENP1.
  • Cellular localization

  • Information by UniProt


  • 12.5% SDS-PAGE analysis of ab152543 stained with Coomassie Blue.


ab152543 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab152543.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact

Sign up