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Neuroscience Neurotransmission Receptors / Channels GPCR Muscarinic Receptors
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Recombinant Human Muscarinic Acetylcholine Receptor 2/CM2 protein (ab152277)

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SDS-PAGE - Recombinant Human Muscarinic Acetylcholine Receptor 2/CM2 protein (ab152277)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human Muscarinic Acetylcholine Receptor 2/CM2 protein
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        SDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSS
      • Amino acids

        251 to 350
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab152277 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • 7TM receptor
      • Acetylcholine receptor, muscarinic, 2
      • AChR
      • Acm2
      • ACM2_HUMAN
      • Cholinergic receptor muscarinic 2
      • Cholinergic receptor, muscarinic 2, cardiac
      • Cholinergic receptor, muscarinic 2, isoform a
      • Cholinergic receptor, muscarinic 2a
      • CHRM 2
      • CHRM2
      • chrm2a
      • CM2
      • FLJ43243
      • HM 2
      • HM2
      • M2
      • M2 muscarinic receptor
      • M2-mAChR
      • MGC120006
      • MGC120007
      • Muscarinic acetylcholine receptor M2
      • Muscarinic M2 receptor
      see all
    • Function

      The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
    • Involvement in disease

      Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
    • Cellular localization

      Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
    • Target information above from: UniProt accession P08172 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Muscarinic Acetylcholine Receptor 2/CM2 protein (ab152277)
      SDS-PAGE - Recombinant Human Muscarinic Acetylcholine Receptor 2/CM2 protein (ab152277)
      ab152277 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab152277? Please let us know so that we can cite the reference in this datasheet.

    ab152277 has not yet been referenced specifically in any publications.

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