Product nameRecombinant Human MyD88 protein (denatured)
See all MyD88 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMRPDRAEAPGPPAM AAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALA EEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDV LLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLD DPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPG TCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKR LIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
Molecular weight39 kDa including tags
Amino acids1 to 309
TagsHis tag N-Terminus
- Anti-MyD88 antibody [4D6] (ab107585)
- Anti-MyD88 antibody [OTI1B4] (ab119048)
- Anti-MyD88 antibody (ab131071)
- Anti-MyD88 antibody [EPR590(N)] (ab133739)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-MyD88 antibody (ab2064)
- Anti-MyD88 antibody (ab28763)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-6X His tag® antibody (ab9108)
Our Abpromise guarantee covers the use of ab139225 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 90 % SDS-PAGE.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol
- Mutant myeloid differentiation primary response 88
- MYD 88
FunctionAdapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
Involvement in diseaseDefects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
Sequence similaritiesContains 1 death domain.
Contains 1 TIR domain.
DomainThe intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
- Information by UniProt
ab139225 has not yet been referenced specifically in any publications.