Recombinant Human Myeloid leukemia factor 1 protein (ab40569)

Description

  • Product name

    Recombinant Human Myeloid leukemia factor 1 protein
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab40569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Preservative: 0.002% Sodium azide
    Constituents: 0.1% Triton-X-100, 0.121% Tris

General Info

  • Alternative names

    • Hls7
    • MLF1
    • MLF1_HUMAN
    • Myelodysplasia myeloid leukemia factor 1
    • Myelodysplasia-myeloid leukemia factor 1
    • Myeloid leukemia factor 1
    • myeloid leukemia factor 1 variant 1
    • myeloid leukemia factor 1 variant 2
    • myeloid leukemia factor 1 variant 3
    see all
  • Function

    Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
  • Tissue specificity

    Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
  • Involvement in disease

    Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
  • Sequence similarities

    Belongs to the MLF family.
  • Post-translational
    modifications

    Phosphorylation is required for binding to YWHAZ.
  • Cellular localization

    Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
  • Information by UniProt

Images

  • Analysis of Myeloid leukemia factor 1 Recombinant Protein.
    4-20% SDS gradient gel. Coomassie blue staining.

References

ab40569 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab40569.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up