Recombinant Human Myosin light chain 3 protein (ab158938)
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- References
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Overview
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Product nameRecombinant Human Myosin light chain 3 protein
See all Myosin light chain 3 proteins and peptides -
Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceEVEFDASKIKIEFTPEQIEEFKEAFMLFDRTPKCEMKITYGQCGDVLRAL GQNPTQAEVLRVLGKPRQEELNT
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Amino acids34 to 106
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158938 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Cardiac myosin light chain 1
- CMH8
- CMLC1
see all -
FunctionRegulatory light chain of myosin. Does not bind calcium.
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Involvement in diseaseDefects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. -
Sequence similaritiesContains 3 EF-hand domains.
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Post-translational
modificationsThe N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human Myosin light chain 3 protein (ab158938)ab158938 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158938 has not yet been referenced specifically in any publications.
