Recombinant Human Natriuretic peptides A protein (ab114317)

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Description

  • Product name

    Recombinant Human Natriuretic peptides A protein

  • Expression system

    Wheat germ

  • Accession

    P01160

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEK MPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRG PWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDGIGAQSGLGCNSFR YRR

    • Predicted molecular weight

      43 kDa including tags

    • Amino acids

      1 to 153

Specifications

Our Abpromise guarantee covers the use of ab114317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form

    Liquid

  • Additional notes

    This protein is best used within three months from the date of receipt.

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • ANF
    • ANF_HUMAN
    • ANP
    • ATFB6
    • Atrial natriuretic factor
    • Atrial natriuretic peptide
    • Atriopeptin
    • Cardiodilatin
    • Cardiodilatin related peptide
    • Cardiodilatin-related peptide
    • Cardionatrin
    • CDD
    • CDD ANF
    • CDD-ANF
    • CDP
    • Natriuretic peptide A
    • Natriuretic peptide precursor A
    • NPPA
    • PND
    • Prepronatriodilatin
    see all

  • Function

    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

  • Involvement in disease

    Atrial standstill 2
    Atrial fibrillation, familial, 6

  • Sequence similarities

    Belongs to the natriuretic peptide family.

  • Post-translational
    modifications

    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Natriuretic peptides A protein (ab114317)
    SDS-PAGE - Recombinant Human Natriuretic peptides A protein (ab114317)
    SDS-PAGE analysis of ab114317 on a 12.5% gel stained with Coomassie Blue.

References

ab114317 has not yet been referenced specifically in any publications.

Publishing research using ab114317? Please let us know so that we can cite the reference in this datasheet.

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