Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMTEEVIV IAKWDYTAQQ DQELDIKKNE RLWLLDDSKT WWRVRNAANR TGYVPSNYVE RKNSLKKGSL VKNLKDTLGL GKTRRKTSAR DASPTPSTDA EYPANGSGAD RIYDLNIPAF VKFAYVAERE DELSLVKGSR VTVMEKCSDG WWRGSYNGQI GWFPSNYVLE EVDEAAAESP SFLSLRKGAS LSNGQGSRVL HVVQTLYPFS SVTEEELNFE KGETMEVIEK PENDPEWWKC KNARGQVGLV PKNYVVVLSD GPALHPAHAP QISYTGPSSS GRFAGREWYY GNVTRHQAEC ALNERGVEGD FLIRDSESSP SDFSVSLKAS GKNKHFKVQL VDNVYCIGQR RFHTMDELVE HYKKAPIFTS EHGEKLYLVR ALQ
    • Molecular weight
      45 kDa including tags
    • Amino acids
      1 to 380
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    ab167862 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Additional notes

    Protein previously labeled as Nck beta.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris-HCl buffer, 0.02% DTT, 30% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • Cytoplasmic protein NCK2
    • GRB4
    • Growth factor receptor bound protein 4
    • NCK adaptor protein 2
    • Nck-2
    • NCK2
    • NCK2_HUMAN
    • NCKbeta
    • Non-catalytic region of tyrosine kinase adaptor protein 2
    • Noncatalytic region of tyrosine kinase beta
    • SH2/SH3 adaptor protein NCK-beta
    see all
  • Function
    Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 SH2 domain.
    Contains 3 SH3 domains.
  • Cellular localization
    Cytoplasm. Endoplasmic reticulum.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab167862 (3µg)

References

ab167862 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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