Recombinant Human NDUFA1 protein (ab158959)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      AYIHRFTNGGKEKRVAHFGYHWSLMERDRRISGVDRYYVSKGLENID
    • Amino acids
      24 to 70
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • CI MWFE
    • CI-MWFE
    • Complex I MWFE
    • complex I MWFE subunit
    • Complex I-MWFE
    • MWFE
    • MWFE, B. taurus, homolog of
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 7.5kDa
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
    • NADH oxidoreductase subunit MWFE
    • NADH ubiquinone oxidoreductase (complex 1)
    • NADH ubiquinone oxidoreductase MWFE subunit
    • NADH-ubiquinone oxidoreductase 1 alpha subcomplex, 1
    • NADH-ubiquinone oxidoreductase MWFE subunit
    • NDUA1_HUMAN
    • NDUFA 1
    • NDUFA1
    • Type I dehydrogenase
    • ZNF 183
    • ZNF183
    see all
  • Function
    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • Tissue specificity
    Primarily expressed in heart and skeletal muscle.
  • Involvement in disease
    Defects in NDUFA1 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similarities
    Belongs to the complex I NDUFA1 subunit family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt

Images

  • ab158959 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158959 has not yet been referenced specifically in any publications.

Publishing research using ab158959? Please let us know so that we can cite the reference in this datasheet.

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