Recombinant Human NDUFA1 protein (ab158959)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human NDUFA1 protein -
Expression system
Wheat germ -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
AYIHRFTNGGKEKRVAHFGYHWSLMERDRRISGVDRYYVSKGLENID -
Amino acids
24 to 70 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab158959 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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Form
Liquid -
Additional notes
Protein concentration is above or equal to 0.05 mg/ml. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- CI MWFE
- CI-MWFE
- Complex I MWFE
see all -
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. -
Tissue specificity
Primarily expressed in heart and skeletal muscle. -
Involvement in disease
Defects in NDUFA1 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. -
Sequence similarities
Belongs to the complex I NDUFA1 subunit family. -
Cellular localization
Mitochondrion inner membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human NDUFA1 protein (ab158959)ab158959 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab158959 has not yet been referenced specifically in any publications.
