The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116433 was purified by proprietary chromatographic techniques and filter sterilized.
ab116433 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 30% Glycerol
CI 18 kDa
Complex I 18 kDa
Complex I AQDQ
Complex I-18 kDa
mitochondrial respiratory chain complex I (18 KD subunit)
NADH coenzyme Q reductase
NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4
NADH ubiquinone oxidoreductase 18 kDa subunit
NADH-ubiquinone oxidoreductase 18 kDa subunit
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Involvement in disease
Defects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.