The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Complex I 23kD
Human mitochondrial NADH dehydrogenase ubiquinone Fe S protein 8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
NADH ubiquinone oxidoreductase 23 kDa subunit
NADH-ubiquinone oxidoreductase 23 kDa subunit
Ubiquinoneiron sulfur protein 8, mitochondrial precursor
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
Involvement in disease
Defects in NDUFS8 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
Belongs to the complex I 23 kDa subunit family. Contains 2 4Fe-4S ferredoxin-type domains.