Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      DLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAA EPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEV WQRRGSLEG
    • Amino acids
      637 to 745
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • C2 and WW domain-containing protein 2
    • E3 ubiquitin protein ligase HECW2
    • E3 ubiquitin-protein ligase HECW2
    • HECT
    • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
    • Hecw2
    • HECW2_HUMAN
    • KIAA130
    • KIAA1301
    • NEDD4 like E3 ubiquitin protein ligase 2
    • NEDD4 Related E3 Ubiquitin Ligase
    • NEDD4-like E3 ubiquitin-protein ligase 2
    see all
  • Function
    E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
  • Tissue specificity
    Predominantly expressed in adult brain, lung and heart.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 C2 domain.
    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 2 WW domains.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human NEDL2 protein (ab163576)
    SDS-PAGE - Recombinant Human NEDL2 protein (ab163576)
    ab163576 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163576 has not yet been referenced specifically in any publications.

Publishing research using ab163576? Please let us know so that we can cite the reference in this datasheet.

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