Recombinant Human NEURL2 protein (denatured) (ab171589)

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Description

  • Product name

    Recombinant Human NEURL2 protein (denatured)

  • Purity

    > 85 % SDS-PAGE.
    ab171589 was purified using conventional chromatography.

  • Expression system

    Escherichia coli

  • Accession

    Q9BR09

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGSMAAASEPVDSGALWGLERPEPPPTRFH RVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGW CGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGR PEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYE LNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLY AVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKE LKDFCKYE

    • Predicted molecular weight

      34 kDa including tags

    • Amino acids

      1 to 285

    • Tags

      His tag N-Terminus

  • Description

    Recombinant Human NEURL2 protein

Specifications

Our Abpromise guarantee covers the use of ab171589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • NEUL2_HUMAN
    • Neuralized like protein 2
    • Neuralized-like protein 2
    • NEURL2

  • Function

    Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

  • Tissue specificity

    Expressed specifically in skeletal and cardiac muscles.

  • Pathway

    Protein modification; protein ubiquitination.

  • Sequence similarities

    Contains 1 NHR (neuralized homology repeat) domain.
    Contains 1 SOCS box domain.

  • Domain

    The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding.

  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (ab171589)
    SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (ab171589)
    15% SDS-PAGE analysis of ab171589 at 3µg.

References

ab171589 has not yet been referenced specifically in any publications.

Publishing research using ab171589? Please let us know so that we can cite the reference in this datasheet.

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