Recombinant Human NEURL2 protein (denatured) (ab171589)

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SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (ab171589)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 85% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Human NEURL2 protein (denatured)

    • Purity

      > 85 % SDS-PAGE.
      ab171589 was purified using conventional chromatography.

    • Expression system

      Escherichia coli

    • Accession

      Q9BR09

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMGSMAAASEPVDSGALWGLERPEPPPTRFH RVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGW CGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGR PEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYE LNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLY AVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKE LKDFCKYE

      • Predicted molecular weight

        34 kDa including tags

      • Amino acids

        1 to 285

      • Tags

        His tag N-Terminus

    • Description

      Recombinant Human NEURL2 protein

    Specifications

    Our Abpromise guarantee covers the use of ab171589 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol (glycerin, glycerine)

    General Info

    • Alternative names

      • NEUL2_HUMAN
      • Neuralized like protein 2
      • Neuralized-like protein 2
      • NEURL2

    • Function

      Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

    • Tissue specificity

      Expressed specifically in skeletal and cardiac muscles.

    • Pathway

      Protein modification; protein ubiquitination.

    • Sequence similarities

      Contains 1 NHR (neuralized homology repeat) domain.
      Contains 1 SOCS box domain.

    • Domain

      The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (ab171589)
      SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (ab171589)
      15% SDS-PAGE analysis of ab171589 at 3µg.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab171589? Please let us know so that we can cite the reference in this datasheet.

    ab171589 has not yet been referenced specifically in any publications.

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