Overview

  • Product name

    Recombinant Human Neurogenin3/NGN-3 protein (denatured)
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSLYALE PPAPHCGELG SPGGSPGDWG SLYSPVSQAG SLSPAASLEE RPGLLGATSS ACLSPGSLAF SDFL
    • Molecular weight

      25 kDa including tags
    • Amino acids

      1 to 214
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab177682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Additional notes

    Previously labelled as Neurogenin3.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 2.4% Urea, 10% Glycerol

General Info

  • Alternative names

    • ATH4B
    • Atoh5
    • bHLHa7
    • Class A basic helix-loop-helix protein 7
    • Math4B
    • NEUROG3
    • Neurogenin-3
    • Neurogenin3
    • NGN-3
    • ngn3
    • NGN3_HUMAN
    • OTTHUMP00000019730
    • Protein atonal homolog 5
    see all
  • Function

    Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
  • Involvement in disease

    Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
  • Sequence similarities

    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab177682.

References

ab177682 has not yet been referenced specifically in any publications.

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