Recombinant Human Neurogranin protein (ab181939)

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SDS-PAGE - Recombinant Human Neurogranin protein (ab181939)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Tags: His tag N-Terminus
    • Suitable for: MS, SDS-PAGE

    Description

    • Product name

      Recombinant Human Neurogranin protein
      See all Neurogranin proteins and peptides

    • Purity

      > 90 % SDS-PAGE.
      ab181939 was purified using conventional chromatography.

    • Expression system

      Escherichia coli

    • Accession

      Q92686

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHHSSGLVPRGSHMGSMDCCTENACSKPDDDILDIPLDDPGAN AAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSG D

      • Predicted molecular weight

        10 kDa including tags

      • Amino acids

        1 to 78

      • Tags

        His tag N-Terminus

      • Additional sequence information

        NP_001119653

    Specifications

    Our Abpromise guarantee covers the use of ab181939 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Mass Spectrometry

      SDS-PAGE

    • Mass spectrometry

      MALDI-TOF

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.00
      Constituents: 30% Glycerol (glycerin, glycerine), 0.002% PMSF, 0.32% Tris HCl, 0.03% EDTA

    General Info

    • Alternative names

      • Protein kinase C substrate RC3
      • Calmodulin binding protein
      • Hng
      • NEUG(55-78)
      • NEUG_HUMAN
      • Neurogranin (protein kinase C substrate)
      • Ng
      • NRGN
      • Protein kinase C substrate
      • RC3
      see all

    • Function

      Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.

    • Tissue specificity

      In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.

    • Sequence similarities

      Belongs to the neurogranin family.
      Contains 1 collagen-like domain.
      Contains 1 IQ domain.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Neurogranin protein (ab181939)
      SDS-PAGE - Recombinant Human Neurogranin protein (ab181939)

      15% SDS-PAGE analysis of 3 µg ab181939.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab181939? Please let us know so that we can cite the reference in this datasheet.

    ab181939 has not yet been referenced specifically in any publications.

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