Product nameRecombinant Human Neuropilin 1 protein
See all Neuropilin 1 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFN PHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIK FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLE CTYIVFALKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIRDGFPDVGP HIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED FKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSY REWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITI KEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVY GCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWA LPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNN GSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHG GLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTG GTTVLATEKPTVIDSTIQSGIK
Molecular weight94 kDa including tags
Amino acids23 to 644
Our Abpromise guarantee covers the use of ab132179 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Best used within three months from the date of receipt.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
- A5 protein
- BLOOD DENDRITIC CELL ANTIGEN 4
FunctionThe membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Tissue specificityThe expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Sequence similaritiesBelongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
ab132179 has not yet been referenced specifically in any publications.