Nucleolar protein interacting with the FHA domain of pKI 67
Nucleolar protein interacting with the FHA domain of pKI-67
Contains 1 RRM (RNA recognition motif) domain.
Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.
Nucleus > nucleolus. Chromosome. Localizes to mitotic chromosomes in conjunction with MKI67.