Overview

  • Product name

    Recombinant Human NIR2 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      27 kDa
    • Amino acids

      213 to 468

Specifications

Our Abpromise guarantee covers the use of ab127088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • DRES9
    • Drosophila retinal degeneration B
    • Drosophila retinal degeneration B homolog
    • FLJ44997
    • membrane-associated 1
    • Membrane-associated phosphatidylinositol transfer protein 1
    • NIR 2
    • NIR-2
    • NIR2
    • OTTHUMP00000236414
    • OTTHUMP00000236415
    • Phosphatidylinositol transfer protein
    • phosphatidylinositol transfer protein membrane associated
    • PITM1_HUMAN
    • PITPNM
    • PITPnm 1
    • Pitpnm1
    • PYK2 N terminal domain interacting receptor 2
    • Pyk2 N-terminal domain-interacting receptor 2
    • RD 9
    • RD9
    • RDGB
    • RDGB1
    • RDGBA1
    • retinal degeneration B alpha 1
    see all
  • Function

    Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
    Contains 1 DDHD domain.
  • Post-translational
    modifications

    Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1.
    Phosphorylated on threonine residues upon treatment with oleic acid.
    Phosphorylated on tyrosine residues by PTK2B.
  • Cellular localization

    Cytoplasm. Golgi apparatus > Golgi stack membrane. Endoplasmic reticulum membrane. Lipid droplet. Cleavage furrow. Midbody. Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis.
  • Information by UniProt

References

ab127088 has not yet been referenced specifically in any publications.

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